The 49-year-old actress took home the trophies for Favourite Movie Actress, Favourite Comedic Actress and Favourite Dramatic Actress, and her partnership with George Clooney in 'Gravity' awarded them Favourite Movie Duo. Additionally, 'The Heat' - in which she starred with Melissa McCarthy - was named Favourite Comedic Movie.
Justin Timberlake paid tribute to his "beautiful wife" Jessica Biel when accepting the Favourite Male Entertainer award, one of three trophies he took home.
Justin - whose album 'The 20/20 Experience' was named Favourite Album and who also won Favourite R&B Artist - said: "I'd like to thank my beautiful wife for teaching me patience and the little things like just putting the dishes in the dish washer. It goes a long way - fellas, you're welcome!"
Meanwhile, talk show host Ellen DeGeneres set a record as the woman who has gained the most People's Choice Awards as she took home Favourite Daytime TV Host, bringing her total haul over the years to 14.
In her acceptance speech, she said: "As a young girl growing up in New Orleans, if anyone would have told me I was going to win 14 People's Choice Awards I ... I mean 12, yes. 13, maybe. But 14?"
Robert Downey Jr. sparked laughter at Los Angeles' Nokia Theatre by getting into character when he picked up the Favourite Action Movie Star award for 'Iron Man 3', a film which was also named Favourite Movie and Favourite Action Movie.
He got on stage and asked the sound of his microphone be changed, the spotlight was on only him and some "triumphant" music was played.
He then said: "I am Iron Man and this is for the people. Thanks a lot this is really a pleasure. Thank you ... people, people, people."
Other winners at the fan-voted awards included 'Glee', Katy Perry - who took home Favourite Music Video for the third year in a row - Demi Lovato, 'The Big Bang Theory' and Jennifer Hudson.
People's Choice Awards selected list of winners:
Favourite Movie Actress:
Sandra Bullock
Favourite Comedic Movie Actress:
Sandra Bullock
Favourite Dramatic Movie Actress:
Sandra Bullock
Favourite Album:
'The 20/20 Experience' -Justin Timberlake
Favourite Male Artist:
Justin Timberlake
Favourite R&B Artist:
Justin Timberlake
Favourite Daytime TV Host(s):
Ellen DeGeneres
Favourite Comedic Movie Actor:
Adam Sandler
Favourite Dramatic TV Actor:
Josh Charles
Favourite Competition TV Show:
'The Voice'
Favourite Network TV Drama:
'The Good Wife'
Favourite Comedic Movie:
'The Heat'
Favourite Pop Artist:
Britney Spears
Favourite Comedic TV Actress:
Kaley Cuoco
Favourite Comedic TV Actor:
Chris Colfer
Favourite Action Movie:
'Iron Man 3'
Favourite Action Movie Star:
Robert Downey Jr.
Favourite Movie:
'Iron Man 3'
Favourite Movie Actor:
Johnny Depp
Favourite Dramatic Movie:
'Gravity'
Favourite Dramatic Movie Actor:
Leonardo DiCaprio
Favourite Family Movie:
'Despicable Me 2'
Favourite Horror Movie:
'Carrie'
Favourite Thriller Movie:
'Now You See Me'
Favourite TV Movie/Miniseries:
'American Horror Story'
Favourite Series We Miss Most:
'Breaking Bad'
Favourite Female Artist:
Demi Lovato
Favourite Breakout Artist:
Ariana Grande
Favorite Country Artist:
Taylor Swift
Favourite Hip-Hop Artist:
Macklemore & Ryan Lewis
Favourite Band:
One Direction
Favourite Alternative Band:
Fall Out Boy
Favourite Song:
'Roar' - Katy Perry
Favourite Music Video:
'Roar' - Katy Perry
Favourite Music Fan Following
Lovatics
Favourite Humanitarian:
Jennifer Hudson
– Bang Media